Memory


 * By Praneeth**
 * The human CREB gene itself lies on chromosome 2 but it cant do its job without CREBBP which lies on chromosome 16. The gene CREB has a lot of functions** but the most important one is related to the brain. This gene helps us have long term memories. CREB also has an important role in the development of drug addiction. The cAMP responsive element binding protein (CREB) is a nuclear protein that modulates the transcription of genes with cAMP responsive elements in their promoters. Increases in the concentration of either calcium or cAMP can trigger the phosphorylation and activation of CREB. Disturbance of CREB function in brain can contribute to the development and progression of Huntington's Disease. Abnormalities of a protein that interacts with the CREB can cause Rubinstein-Taybi syndrome. CREB is also thought to be involved in the growth of some types of cancer.

Term: Amnesia = loss of large block of memories ; Pg. 229 ; three young people with severe amnesia for facts and events

The thing that suprised me was that the scientists used snails, and fruit flies to learn about this gene. It just suprises me how tehy could use such a little brain and find the right chromsome and right gene and then learn about. It probably took them a long time to do all this. And also I would love learn more about this gene in detail it seems like a gene that would be the most interesting since it has to do with memory.